Short answer: No.
The bottom line is that discovery of huge amounts of oil or natural gas in currently unexplored areas of the central and northern Gulf is very unlikely, because the geology doesn't support it.
There might be significant amounts of oil off South Florida, but it is heavy oil that is very difficult to clean up if a spill occurs.
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[W]hile there is oil and natural gas still to be found in the eastern Gulf of Mexico, it is not sufficient to solve our energy problems.